Abstract

AN APPROACH TO ENHANCE DISSOLUTION RATE OF POORLY WATER SOLUBLE DRUG BY SOLID DISPERSION TECHNIQUE

Remidala Pravalika*, K. Priyanka and K. Santhosh Naik

Abstract

Rosuvastatin is an anti-hyper-lipidemic drug. It is a poorly water soluble drug. It belongs to class II in BCS classification. The present research work is to increase the solubility of the Rosuvasttin by solid dispersion technique. Solid dispersions were prepared by solvent evaporation method by using various hydrophilic carriers in various drug and carrier ratios. Among all the formulations of solid dispersions 1:7 (drug: Mcc) ratios was shows rapid drug release. Hence this ratio was optimized for further preparation of fast dissolving tablets of Rosuvastatin. Fast dissolving tablets were prepared by direct compression method by using various super disintegrates in various proportions F6 formulation (contains 2% crospovidone) shows rapid drug release when compared with other formulations. Hence F6 formulation was optimized as new dosage form.

Keywords: Solid dispersions, Rosuvastin, Urea, Mcc, Crospovidone, Crosecormellose Sodium.