Abstract

ACUTE AND CHRONIC ANTI-INFLAMMATORY STUDY OF ETHANOLIC EXTRACT OF OCHNA OBTUSATA LEAVES

V. Ravi Kumar* and Dr. L. Srinivas

Abstract

Since the leave extracts of Ochna obtusata is reportedly used to treat ulcer, asthma and bronchitis, an attempt was made to study the Anti- Inflammatory activity of leaves of Ochna obtusata. Ethanolic extracts was prepared and used for the evaluation. The anti-inflammatory activity of EEOO was studied by reported methods to check acute and chronic anti-inflammatory activity. The acute study was performed in rat model by forming five groups with six rats in each group. Group – I served as Negative control, Group – II served as positive control (Diclofenac sodium 10mg/kg p.o), Group – III (EEOO 100mg/kg p.o), Group – IV (EEOO 200mg/kg p.o) and Group – V (EEOO 400mg/kg p.o) served as tests. The chronic study was also studied in the same way by replacing using Dexamethasone 2.5mg/kg p.o towards positive control.

Keywords: Ochna obtusata, Ethanolic extract, Carreegeenan, Xylene, Cotton pellet.