Abstract

AN EVALUATION OF ANTIBACTERIAL POTENTIAL OF MEDICINAL PLANT CROTON BONPLANDIANUM AGAINST SOME PATHOGEN ISOLATED FROM COMPLICATED URINARY TRACT INFECTIONS (UTI): ALTERNATIVE APPROACHES OF CONVENTIONAL TREATMENT

Tanmay Ghosh*, M. K. Biswas and Pradipta Roy

Abstract

Medicinal plants produce several antibacterial compounds. These plants are well known for their medicinal value and are widely used in community for the treatment of various diseases. It was a study to investigate the Antibacterial Activity of Croton bonplandianum Plants Used against UTI Causing Pathogens. Bacteria were isolate from the UTI infected patient and characterized by using microscopic, staining, morphological and biochemical methods. Organic compounds with plant were extracted using a various concentrations and these extracts were than to check their antibacterial activity against the bacteria isolated from UTI infected patients and the zone of inhibition were compared with the zone of inhibition of standard antibiotics. Results from the present study showed that the extracts of C. bonplandianum had more antibacterial activity compared to antibiotics. Hexane, Ethyl Acetate, Ethanolic and Chloroform Extracts of C.bonplandianum were used for studying antibacterial activity by agar well diffusion assay and Minimum inhibitory concentration method. Among the four extracts used, highest antibacterial activity was recorded with ethyl acetate extract on E.coli and least against Staphylococcus haemolyticus with diameter of inhibition zones (DIZ) of 2.96 ± 0.57 and 2.79 ± 0.57 mm respectively and at parallel way among four extract highest antibacterial activity recorded with UTI cure antibiotic with Ciprofloxacin on Enterobacter aerogenes and least against E.coli with diameter of inhibition zones of 2.66±0.23 and 2.0±0.23mm respectively. Preliminary phytochemical analysis of the plant parts revealed the presence of active compounds such as phenolics, tannins, alkaloids and flavonoids. This study highlights the need to exploit the antibacterial potential of these plants for development of new antibiotics.

Keywords: Croton bonplandianum, Staphylococcus haemolyticus, E.coli.