Abstract

COMPARITIVE STUDY OF SOLANUM XANTHOCARTUM AND SILYMARINE IN PARACETAMOL INDUCED LIVER DAMAGE

P. Sangeetha and Dr. J. Thirumagal*

Abstract

Liver is one of the largest organs in human body and the chief site for intense metabolism and excretion. Therefore, it has an important role in the maintainance, performance and regulating homeostasis of the body. It is involved with almost all the biochemical pathways to growth, fight against disease, nutrient supply, energy provision and reproduction. It is an important organ for detoxification of xenobiotics, environmental toxicants and liver damage is associated with distortion of several metabolic functions; hence liver diseases are of serious health problem. Prolonged drug therapy, excessive use of the some of the commonly used medicines like paracetamol, diclofenac etc., alcoholism, exposure to certain xenobiotic, polutants and certain disease state have been reported to affect liver functioning. Effectively, herbal products are widely used in the treatment of hepatic disorders all over the world. In the absence of reliable liver protective drugs in allopathic medical practices, naturally occurring compounds have been found to have major role in the management of various liver diseases. Numerous medicinal plants and their formulations are used for liver disorders in ethnomedical practices and in traditional systems of medicine in India.

Keywords: Hepatocytes, Paracetamol, Sillimarin, Sollanum xanthocartum.