Abstract

NANOSTRUCTURED LIPID CARRIER (NLC): A MODERN APPROACH FOR INTRANASAL DRUG DELIVERY

Pingale A. M.*, Gondkar S. B. and Saudagar R. B.

Abstract

Drugs as such can be delivered in the body using different routes but most of the routes have its own limitations like poor solubility, absorption, first pass metabolism and poor bioavailability, hence need for this nanostructured based drug delivery systems was developed. Nanostructured lipid carriers (NLC) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. This technique not only will help us in overcoming the above mentioned drawbacks but also this helps us in reducing the dose, systemic side effects and delivering the drugs to the site of action. These nano based systems can be used to deliver variety of drugs through different routes of administration including oral, topical, transdermal, ocular, nasal and parenteral. This review describes the preparation techniques and application of NLC are systematically elucidated in this review.

Keywords: Nano- structured lipid carriers, Nanoparticle, Novel approach, Bioavailability, Targeted drug delivery.