Abstract

LIPOSOMES: AS TARGETED DRUG DELIVERY SYSTEM

Sadhana Noothi* and K. Maheswari

Abstract

The need to deliver drugs specifically to targets within the body was recognized early last century (1906) by Paul Ehrlich. Drugs administered as such are known to exhibit a variety of toxic effects because of their nonspecific distribution in the body, acting on diseased and healthy tissues alike. Targeting of drugs was initially attempted by the use of antibodies (O‟Neill 1979). It was thought that linking of a cytotoxic drug to an antibody raised against a cell type would deliver the drug to that cell. However, success in tumour bearing animals and humans was only modest and it had to await the development of monoclonal antibodies to obtain promising clinical results.

Keywords: .