Abstract

AN OPEN CLINICAL TRIAL TO ASSESS THE EFFICACY OF NIRGUNDYADI GRITHA AS AN ADD-ON THERAPY ALONG WITH AED IN THE MANAGEMENT OF APASMARA WSR TO PARTIAL SEIZURE WITH SECONDARY GENERALIZATION

C Ambili , M Jithesh, S Ram manohar

Abstract

Epilepsy is the most common presentation in a neurological setting and stands next to stroke and dementia in its prevalence. One third of the people with epilepsy seems to be severely affected and continues to have seizure despite all the available medications. The disease and its management have high impact on the quality of life of the affected person and also discrimination in education, employment and social acceptance. In Ayurveda, the disease named ‘Apasmara’ has been explained with its aetiology, symptoms, diagnosis and management. A psycho neurological approach has been explained for managing the condition of Apasmara and it is explained in a medical as well as psychological setting. The approach includes a systematic one, depending on the severity and enormity of the associated doshas. Many a drugs are also mentioned in this regard, but has not been assessed statistically and the available data is based on the clinical finding only. Aim: To assess the efficacy of Nirgundyadi gritha in the management of Apasmara WSR to partial seizure with secondary generalisation Setting: Kayachikitsa and Manasroga OPD, VPSV Ayurveda College, Kottakkal, India. Method: An open label uncontrolled clinical trial with sample size 20. Add on usage of Nirgundyadi gritha was done without withdrawing the ongoing AED and those with seizure. Assessment was done after one month, 2 months and after 1 month of followup. Result- It was observed that the selected drug has significant efficacy in the management of apasmara wsr to partial seizure with secondary generalisation. The drug Nirgundyadi gritha is effective in the management of Apasmara and to improve the quality of life of the affected ones.

Keywords: Apasmara, Epilepsy, Nirgundyadi gritha, AED, EEG.