Abstract

ANTIMICROBIAL ACTIVITY OF PAEDERIA FOETIDA EXTRACTAGAINST DRUG RESISTANT HELICOBACTER PYLORI ISOLATES FROM INDIA

Silpi Chanda*,Valentina Gehlot,Rajashree Das,Shweta Mahant,Kunal Das,Kuldeep Singh,Sayeed Ahmad

Abstract

Treatment failure is a major cause of concern for the Helicobacter pylorirelated gastroduodenal diseases like gastritis, peptic ulcer and gastric cancer. The antibacterial activity of Paederiafoetidaagainst few clinical isolates of H.pyloriin vitro was evaluated. The methanolicleaf extractshowing its effectiveness in inhibiting in vitroH. pylori growth irrespective of the genetic makeup of the strains. This study provides novel insights into the therapeutic effect of P. foetidaagainst H. pylori infection, suggesting its potential as an alternative therapy, and opens the way for further studies on identification of novel antimicrobial targets of P. foetida.

Keywords: Helicobacter pylori, Paederia foetida.