A REVIEW ON: PHARMACOSOMES AS A NOVEL VESICULAR DRUG DELIVERY SYSTEM
*Jitendra L Patel1, Praful D Bharadia2
Abstract
Various types of lipid based vesicular systems have been developed in
controlled and targeted drug delivery system. Pharmacosomes is a
novel vesicular drug delivery system, bearing unique advantages over
liposome and noisome have come up as potential alternative to
conventional vesicles. Pharmacosomes are the amphiphilic
phospholipids complexes of drugs bearing active hydrogen that bind
to phospholipids. They provide an efficient method for delivery of
drug directly to the site of infection, leading to reduction of drug
toxicity with no adverse effects and also reduces the cost of therapy
by imparting better biopharmaceutical properties to the drug, resulting
in improved bioavailability, especially in case of poorly soluble drugs.
Pharmacosomes have been prepared for various non-steroidal antiinflammatory
drugs, proteins, cardiovascular chemotherapeutic agents
and antineoplastic drugs. This article reflects the potential of pharmacosomes as a controlled
and targeted drug delivery system and focuses the methods of preparation and
characterization.
Keywords: Pharmacosome, Vesicular drug delivery system, Phospholipids, bioavailability, amphiphilic.
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