Abstract

A REVIEW ON: PHARMACOSOMES AS A NOVEL VESICULAR DRUG DELIVERY SYSTEM

*Jitendra L Patel¹, Praful D Bharadia²

Abstract

Various types of lipid based vesicular systems have been developed in controlled and targeted drug delivery system. Pharmacosomes is a novel vesicular drug delivery system, bearing unique advantages over liposome and noisome have come up as potential alternative to conventional vesicles. Pharmacosomes are the amphiphilic phospholipids complexes of drugs bearing active hydrogen that bind to phospholipids. They provide an efficient method for delivery of drug directly to the site of infection, leading to reduction of drug toxicity with no adverse effects and also reduces the cost of therapy by imparting better biopharmaceutical properties to the drug, resulting in improved bioavailability, especially in case of poorly soluble drugs. Pharmacosomes have been prepared for various non-steroidal antiinflammatory drugs, proteins, cardiovascular chemotherapeutic agents and antineoplastic drugs. This article reflects the potential of pharmacosomes as a controlled and targeted drug delivery system and focuses the methods of preparation and characterization.

Keywords: Pharmacosome, Vesicular drug delivery system, Phospholipids, bioavailability, amphiphilic.