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Abstract

DEVELOPMENT AND EVALUATION OF A SUSTAINED RELEASE MICROENCAPSULES OF THEOPHYLLINE

Shidhaye Supriya Shrihari1, Surve Chaitali Vibhakar

Abstract

A sustained release dosage form of Theophylline in the form of microspheres was prepared by the solvent evaporation method. Solvent evaporation method was attempted in oily manufacturing vehicles. Different polymers such as Ethyl Cellulose, Eudragit® RS PO, Eudragit® RL PO, Eudragit® S 100,Eudragit® RL 100 and different combinations of these polymers were tried and the resulting microspheres were evaluated for entrapment efficiency, drug loading and percent yield of the process and dissolution profile. The aim was to develop a multiparticulate sustained release drug delivery system to be converted to a orally disintegrating formulation, so that patient suffering from dysphagia, stroke, difficulty in swallowing, paediatric, geriatric patients etc. may consume it easily and long term therapy may be maintained as required in patients suffering from osteoarthritis, diabetes.

Keywords: Theophylline, microspheres, solvent evaporation, taste masking, orally disintegrating, factorial design.


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