Abstract

COMPARATIVE EFFECT OF AQUEOUS AND ETHANOLIC EXTRACTS OF TETRAPLEURA TETRAPTERA (AIDAN) FRUIT ON SOME HAEMATOLOGICAL PARAMETERS OF FEMALE WISTAR RATS

Justina Nwadinma Nwangwa, Augustine Lishilinimye Udefa*, Beshiunim Akunke Apuye and Peace Iso Assim-Ita

Abstract

Extracts of Tetrapleura tetraptera have been employed in the management and treatment of various ailments. This study examined and compared the effects of aqueous and ethanolic extracts of Tetrapleura tetraptera fruit on some haematological parameters in female wistar rats. 15 female wistar rats (180-200g) fed with rat feed and water ad libitum were randomly assigned into three groups (n=5) thus: control, aqueous and ethanolic groups. The three groups were treated with daily oral administration of 0.2mL normal saline, aqueous (60mg/kg body weight) and ethanolic (40mg/kg body weight) extracts of Tetrapleura tetraptera respectively for 21 days. Blood samples were collected from each animal through cardiac puncture for haematological analysis. Red cell indices, platelets count and platelet large cell ratio were not significantly different among the three groups. Mean platelet volume and platelet distribution width were significantly decreased in aqueous (p

Keywords: Extract; Haematological parameters; platelet; red blood cell; Tetrapleura tetraptera; white blood cell.