Abstract

NEPHROPROTECTIVE ACTIVITY OF STEM EXTRACT OF CARALLUMA UMBELLATA HAW AGAINST CISPLATIN AND GENTAMICIN INDUCED NEPHROTOXICITY

G.V. Sampath Kumar and Ch. Sandhya

Abstract

Hydro-alcoholic extract (70% methanol extract) of stems of Caralluma umbellata Haw was subjected to preliminary phytochemical screening by qualitative tests and nephroprotective activity was assessed in gentamicin and cisplatin induced renal damage in wistar rats (150-200 g) by standard methods. The protective property of 70% methanol extract was assessed by measuring the levels of body weight, blood urea nitrogen, serum creatinine and total protein in administered doses. The extract significantly reduced the renal damage caused by cisplatin and gentamicin at a dose of 500 mg/kg.

Keywords: Caralluma umbellate Haw, Blood urea nitrogen, Creatinine, Cisplatin, Gentamicin, renal damage.