Abstract

RED PIGMENT EXTRACT OF SERRATIA MARCESCENS IS ABLE TO INDUCE CHANGE IN CANCER STEM CELL POPULATION (CD44 HIGH) OF METASTATIC PROSTATE CANCER CELL LINES DU145 & PC3.

Maithili A. Athavale*, Gayatri A. More, Smera Satish and Sangeeta A. Srivastava

Abstract

Purpose: The aim of the study was to evaluate anticancer stem cell property of Red Pigment Extract (RPE) of Serratia marcescens on CD44 high cells of two breast viz. MCF-7, MDAMB231 and two prostate viz. DU145 and PC3 cancer cell lines. Methods: The effect of RPE of Serratia marcescens on breast and prostate cancer cell lines was checked by incubating breast (MCF7, MDAMB231) and prostate (DU145, PC3) cancer cell lines with RPE at inhibitory concentration 5 (IC5) for 72 hours at 370C, 5% CO2 in the respective cell culture media. The change induced by RPE on CD44 high cells was checked by Fluorescent Acquired Cell Sorter (FACS). Results: Our results indicated that RPE is able to induce change in CD44 high cells of only prostate (p

Keywords: Red Pigment Extract (RPE), Serratia marcescens, Cancer stem cells, CD44 high, DU145, PC3.