Abstract

INHIBITION OF CALCIUM OXALATE CRYSTALLIZATION BY THE LEAVES EXTRACT OF KALANCHOE PINNATA

P. Elambarathi*, P. Kumar, M. Sivaperumal

Abstract

In the present study the leaves of Kalonchoe pinnata have been selected for their antiurolithiatic activity. The extract was subjected to phytochemical screening and found to contain flavanoid, phenolic compounds and saponins. The given research work was studied under in vitro conditions using two critical assays such as crystal nucleation and aggregation assay. The inhibitory potential alcoholic extract of the Kalonchoe pinnata were tested for the Calcium oxalate crystal formation, which are predominantly present in most of the kidney stones, under in vitro conditions. The nucleation and aggregation of calcium oxalate crystals were measured separately using Spectro -photometric methods. A result obtained showed that alcoholic extract Kalonchoe pinnata has the higher capacity to inhibit the crystal formation and aggregation.

Keywords: Kidney stones, Kalonchoe pinnata, nucleation assay, aggregation assay.