WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

COMPARATIVE EFFECTS OF VITAMIN E AND ITS COMBINATION WITH VITAMIN C ON ENDOTHELIAL FUNCTION IN DIABETIC HYPERTENSIVE PATIENTS

Muhammad Imran Shaikh*, Muhammad Ali Ghoto, Abdullah Dayo, Noor Jahan, Omair Anwar Mohiuddin

Abstract

To compare the antioxidant effect of vitamin E alone and its combination with vitamin C on endothelial dysfunction in patients with diabetes mellitus, a prospective, randomized controlled, parallel group, interventional study was conducted to record flow mediated dilation (FMD) of the brachial artery in 167 diabetic patients. Out of these, 61(39%) were smokers and 97(52%) were Hypertensive. The interventional group was treated with Vitamins E (400mg/day) for first six weeks and with both vitamin E (400mg/day) and vitamin C (500mg/day) for later six weeks of study. No significant variation in FMD% was recorded in the control group while for interventional group significant increase in FMD% was recorded. Within interventional group, addition of vitamin C in existing vitamin E therapy significantly improved endothelial function in all diabetic patients (Individual therapy v/s combination therapy: 7.30±1.47 v/s 8.75±1.65; p≤0.05); smokers: (6.99±1.42 v/s 8.59±1.92; p≤0.05); nonsmokers (7.48±1.48 v/s 8.85±1.48; p≤0.05); hypertensive patients (6.94±1.41 v/s 8.49±1.53; p≤0.05) and nonhypertensives (7.82±1.40 v/s 9.15±1.75; p≤0.05). Results obtained from the current study clearly indicate the beneficial effects of vitamin E on FMD in patients with diabetes and were further augmented by the addition of vitamin C in therapy. Maximum improvement in FMD was recorded in nonsmoker-nonhypertensive diabetic group.

Keywords: Antioxidant, Diabetes, Hypertension, Flow mediated dilation.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More