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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.453

ICV : 90.8

WJPR Citation

	All	Since 2020
Citation	8502	4519
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World Journal of Pharmaceutical Research (WJPR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

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Dr. Dhrubo Jyoti Sen
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Abstract

THE HEN'S EGG TEST - CHORIO-ALLANTOIC-MEMBRANE (HET - CAM) AND HAEMOLYSIS STUDY AS AN ALTERNATIVE TEST FOR OCCULAR IRRITANCY ANIMAL EXPERIMENTS (Draize Test)

Deepak G. Wagh* and Dr. Sadhana R. Shahi

Abstract

Human eyes are frequently exposed to chemicals accidentally or on purpose due to their external location. Therefore, chemicals are required to undergo the evaluation of the ocular irritancy for their safe handling and use before release into the market. Draize rabbit eye test developed in 1944, has been a gold standard test which was enlisted as OECD TG 404 and OECD TG 405 but it has been criticized with respect to animal welfare due to invasive and cruel procedure. To replace it, diverse alternatives have been developed: (i) Hen Egg Test- Chorio-Allantoic-Membrane (HET-CAM) test (ii) RBC Haemolysis study.

Keywords: Hen Egg Test-Chorio-Allantoic-Membrane (HETCAM) test and RBC Haemolysis study.

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