Abstract

PHARMACOLOGICAL EVALUATION OF OXALIS DEHRADUNENSIS RAIZADA (LEAF EXTRACT) FOR ANALGESIC AND ANTIPYRETIC ACTIVITY ON WISTAR RATS

Narendra Bhatrolla*, Tirath Kumar and Janmejay Pant

Abstract

Oxalis dehradunensis Raizada (oxalidaceae) is one of the important medicinal plants used traditionally for the treatment of fever, pain, inflammation and wound healing. The present study was aimed to validate folk use of oxalis dehradunensis Raizada as analgesic and antipyretic remedy. The analgesic activity of methanolic extract of oxalis dehradunensis Raizada was performed by hot plate, tail flick and tail immersion methods, while antipyretic activity was performed by Brewer’s yeast induced pyrexia method. The extract was screened at the dose of 200mg/kg and 400mg/kg by P.O. route. The drugs diclofinac sodium (10mg/kg P.O.) and paracetamol (150mg/kg P.O.) were taken as standard. Pyrexia was induced by 10ml/kg of 15% suspension of brewer’s yeast in 0.9% saline S.C. route. The study therefore, supports its use in folk medicine both as analgesic and antipyretic agent and calls for further investigations to elucidate its mechanism of action.

Keywords: Oxalis dehradunesis Raizada analgesia, pyrexia, diclofenac, PCM.