Abstract

PHARMACOLOGICAL EVALUATION OF STYPTIC ACTIVITY OF MOOLAROGA CHOORANAM FOR THE TREATMENT OF BLEEDING PILES

Anbarasan B.*, Indumathy V., Anbu N. and Kanakavalli K.

Abstract

Varicosities of haemorrhoidal veins called Haemorrhoids or Piles is referred as Moola noi in traditional Siddha system of medicine which is one of ancient traditional medicinal system originated in South India. There are 21 types of Piles is described in Siddha Literature. One among them is Rattha Moolam i.e. Bleeding piles. Bleeding piles is often described as 1st degree internal haemorrhoids. The aim of the present study is to evaluate the potency of the Siddha herbal formulation Moolaroga chooranam to stop bleeding through prolongation of bleeding, clotting and prothrombin time. The study was conducted at Centre for Lab animal Technology and Research, Sathyabama University, Chennai. Wistar albino male rats were used for the study. The animals were grouped into four groups of 6 animals each. Group I (Control group) -received normal saline 5ml/kg, Group II – Aspirin control received 5mg/kg of aspirin, p.o. for 35 days. Group III - Received Aspirin (5mg/kg) for 21 days and then treated with 200mg/kg Moolaroga chooranam, p.o one hour prior to Aspirin administration from day 22 to 35. Group IV - Received Aspirin (5mg/kg) for 21 days and then treated with 400mg/kg Moolaroga chooranam, p.o one hour prior to Aspirin administration from day 22 to 35. There was significant change in bleeding, clotting and prothrombin time.

Keywords: Bleeding piles, Styptic activity, Moolaroga chooranam, Aspirin.