Abstract

BILAYER TABLET: A PROMISING DOSAGE FORM WITH DESIGNING CHALLENGES

Garima Garg*, S. K. Gupta, Rajat Kumar and Vipin Kumar Garg

Abstract

Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bilayer tablet is improved beneficial technology to overcome short coming of single layer tablet.Bilayer (and multilayer) tablets are gaining more acceptances among brand and generic products due to advanced delivery strategies, patient compliance and combination therapy. Bilayer tablet is also suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release and other is sustained release. In this article we review the state-of-the-art of bilayer tablet technology, highlighting the main advantages of bilayered oral dosage forms while incorporating current challenges and advances encountered during manufacturing. The available manufacturing equipment for bilayer tablet production is also described briefly.

Keywords: Tablet technology, bilayer tablets, compaction pressure.