Abstract

AN INTRODUCTION TO THE SYNTHETIC METHOD AND PHARAMCOLOGICAL ACITVITY OF OXADIAZOLE NUCLEUS: A REVIEW

Hricha Joshi*, Ajay Singh Bisht and Divya Juyal

Abstract

Oxadiazole contains an oxygen atom at the 1st position and two nitrogen atom at the 3rd and 4th position which is a derivative of furan by substitution of two methylene group (=CH) with two pyridine type nitrogen atom(-N=). Oxadiazole is a heterocyclic compound belonging to the class of diazoles which exhibit a wide variety of pharmacological activities like anti-bacterial, anti-fungal, anti-oxidant, anti-inflammatory, anti-cancer, anti-tumor, analgesic, due of the ability of the oxadiazole to undergo various chemical reaction. The activity of the compounds depend upon the substitution being taken place in the oxadiazole ring. The present review article has discussed the oxadiazole chemistry, properties, reactivity, synthetic methods of oxadiazole, marketed drugs containing oxadiazole nucleus and certain pharmacological activities.

Keywords: Oxadiazole, diazoles, pharmacological activities, synthetic methods.