A REVIEW ON LIQUISOLID TECHNOLOGY
*Ashish Pathak, Rajkumar Goyal, Preeti Agrawal, Sarlesh Rajput, Gourav Tiwari, Rituraj Shivhare
Abstract
Liquisolid system is a novel concept of drug delivery via oral route.
Solubility is the phenomenon of dissolution of solid in liquid phase
and is one of the important parameter to achieve desired concentration
of drug in systemic circulation for pharmacological response. Poorly
water soluble compound’s oral administration often require high
doses in order to reach therapeutic plasma concentrations because
insufficient dissolution rate of the drug is the limiting factor in the
oral bioavailability and one of the most challenging aspects of drug
development. Various techniques are used for the improvement of the
aqueous solubility, dissolution rate, and bioavailability of poorly
water soluble drugs include micronization, chemical modification, pH
adjustment, solid dispersion, complexation, co‐solvency, micellar
solubilization, hydrotropy etc. A more recent technique, “powdered solution technology” or “Liquisolid technology”, has
been applied to prepare water-insoluble drugs into rapid-release solid dosage forms. In this
case, even though the drug is in a solid dosage form, it is held within the powder substrate in
solution or, in a solubilized, almost molecularly dispersed state, which contributes to the
enhanced drug dissolution properties. Increase in dissolution rate and in turn improvement in
bioavailability is observed in case of poorly water soluble drugs. By use of this technique,
liquid medications such as solutions or suspensions of water insoluble drugs in suitable nonvolatile
liquid vehicles can be easily converted into powder with acceptable flow properties
and compression behavior using suitable powder excipients.
Keywords: Dissolution, Pharmacological response, Bioavilability,Liquisolid technology, Poorly water soluble drugs, Liquid medication.
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