Abstract

A REVIEW ON LIQUISOLID TECHNOLOGY

Abstract

Liquisolid system is a novel concept of drug delivery via oral route. Solubility is the phenomenon of dissolution of solid in liquid phase and is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Poorly water soluble compound’s oral administration often require high doses in order to reach therapeutic plasma concentrations because insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability and one of the most challenging aspects of drug development. Various techniques are used for the improvement of the aqueous solubility, dissolution rate, and bioavailability of poorly water soluble drugs include micronization, chemical modification, pH adjustment, solid dispersion, complexation, co‐solvency, micellar solubilization, hydrotropy etc. A more recent technique, “powdered solution technology” or “Liquisolid technology”, has been applied to prepare water-insoluble drugs into rapid-release solid dosage forms. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties. Increase in dissolution rate and in turn improvement in bioavailability is observed in case of poorly water soluble drugs. By use of this technique, liquid medications such as solutions or suspensions of water insoluble drugs in suitable nonvolatile liquid vehicles can be easily converted into powder with acceptable flow properties and compression behavior using suitable powder excipients.

Keywords: Dissolution, Pharmacological response, Bioavilability,Liquisolid technology, Poorly water soluble drugs, Liquid medication.