Abstract

EFFECT OF HYDROCORTISONE IN SOME FEMALE WHITE LABORATORY MICE ORGANS

Sami J. Al-Maliki, Ali A. Al-Ali and Alaa S. -Kathim*

Abstract

The current study evaluated the resulting pathological tissue in some mice When injected with a dose of the hormone hydrocortisone Mus musculus L. Laboratory. All groups included 8 mice, the first group gave the saline solution, As a control group, the second group was injected with hydrocortisone with a dose of 0.21mg / kg. The histological examination of liver and kidney sections showed dosedependent pathological changes when compared with a group Of some liver cells and blood necrosis. Necrosis and degeneration, and the liver was the occurrence of degeneration. In the portal and central veins a as well as the presence of hemorrhage Expansions and Congestion expansion. Inflammatory cells in different parts of the body. Infiltration changes in the papillary area and hemorrhage. Sloughing In the kidney, some of the tubing of the lining of the protrusions have been degraded while other cells have been observed Some cells lining the protrusions as well as congestion, bleeding and inflammation of inflammatory cells in the capsules.

Keywords: Hydrocortisone, Histopathology, Liver, Kidney, Glucocorticoids.