Abstract

NEUROPHARMACOLOGICAL EVALUATION OF SESBANIA SESBAN USING EXPERIMENTAL ANIMALS

M. S. Kale*, S. U. Kolhe and Dr. S. V. Tembhurne

Abstract

The extension of the expectancy of life and ageing of populations on a global level in recent times are expected to cause a huge rise in the occurrence of many chronic, progressive, non-communicable conditions inclusive of neurological disorders. This has stimulated the use of a variety of medicinal plants containing numerous chemical constituents to provide therapeutic effects similar to those drugs obtained from other sources, with lesser or no side effects. The current study includes the use of ethanolic extract of Sesbania sesban which are evaluated for their neuropharmacological activities.The different types of animals models used for neuropharmacological evaluation consisted of elevated plus maze test, radial arm maze test and conditioned place preference chamber test. The estimation of dopamine in rat brains was also carried out using UV-visible spectroscopy. The extract was found to possess anxiolytic, partially nootropic and non-addictive properties from the results obtained.

Keywords: Conditioned place preference, dopamine, elevated plus maze, neuropharmacological, radial arm maze.