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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

INVITRO CYTOTOXIC ACTIVITY OF LEAVES OF HIBISCUS SABDARIFFA L. AGAINST HEPG2 CELL LINE

S. Sangeetha and T. Ananthi*

Abstract

The aim of the present study was to evaluate in vitro cytotoxic activity of ethanolic extract of leaves of Hibiscus sabdariffa on HepG2 cell lines. Qualitative phytochemical screening tests were performed to detect phytochemicals in the extract. The cytotoxic activity of the extracts of Hibiscus sabdariffa on HepG2 cells was investigated in vitro through MTT assay. The results showed decreased cell viability and increased cell growth inhibition in a dose dependent manner. From the results it can be concluded that Hibiscus sabdariffa possess potential of bioactive components which are responsible for biological activities that is useful for liver cancer treatment.

Keywords: Hibiscus sabdariffa, MTTassay, HepG2, dose dependent.

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