Abstract

DEVELOPMENT AND EVALUATION OF ANTIFUNGAL GEL BY USING NATURAL POLYMER

Shailaja Dombe*, Arti Disale, Reshma Pandhare, Simaran Sutar

Abstract

In the present study, an attempt has been made to formulate the topical drug delivery system of Oxiconazole Nitrate in the form of Hydrogel. Oxiconazole Nitrate is widely used antifungal agent for fungal disease. The sample Oxiconazole Nitrate was firstly characterized for its identification by using physical characterization like melting point, FTIR and DSC. Hydrogels were developed using gelling agent, carbopol 934, Aloe vera and Carageenan. All the formulation developed were evaluated for the post formulation studies like visual inspection, pH, viscosity, spreadability, drug content, In-vitro drug release and Antifungal studies. All the result observed was within official limit. Formulation developed using Aloe vera (F6) show acceptable value as compared to hydrogel developed using other polymers. No phase separation was observed in F6 formulation. Drug content was found to be 96.91%, Spreadability 7.5 g.cm/sec, Viscosity 1025 cps, In-vitro drug release 65.64 %, Antifungal activity for A. Niger with 20mm zone of inhibition for F6 formulation. It was found that pH of all the formulation is in the range of 6.7 to 6.8 that suits the skin pH indicating skin compatibility. From the above study we have concluded that the topical gel prepared from the Aloe vera having good spreadability, bioadhesive strength and soothening effect. So the topical gel prepared from Aloe vera will be greatly for making an ideal topical preparation with no extra addition of smoothening effect.

Keywords: Aloe Vera, Antifungal Gel, Oxiconazole Nitrate, Hydrogel.