FORMULATION AND EVALUATION OF BILAYER TABLET OF AMBROXOL HCL AND DESLORATADINE FOR THE TREATMENT OF SEASONAL ALLERGIC RHINITIS ASSOCIATED WITH COUGH.
Sonia Sharma* and Shweta Agarwal
Abstract
The present study was intended at raising a bilayer drug delivery
system containing Ambroxol HCL and Desloratadine for the treatment
of moderate seasonal allergic rhinitis (SAR), to reduce the dose
frequency and to improve the prolongation of action. The tablet is
characterize by conventional release of Desloratadine and sustained
release of Ambroxol HCl. The formulation containing sustained
release layer of Ambroxol HCl, was designed using HPMC-5 CPS as
sustained release polymer, MCC as drug binder, Aerosil to improve
flow properties of powder, and Magnesium stearate as antiadherent
agent. Crosspovidone was used as superdisintegrant for the preparation
of conventional release layer. The prepared sustained release layer was evaluated for their
pre-compression parameters, physical characteristics like hardness, friability, and weight
uniformity, disintegration, and uniformity of drug content and in- vitro drug release. The
release of Desloratadine from the conventional release layer was found to be within 30 min.
The release of Ambroxol HCl for sustained release layer was found to be in 6 hours.
Keywords: Ambroxol HCL, Desloratadine, bilayer tablet, crosspovidone, superdisintegrant.
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