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Abstract

FORMULATION AND EVALUATION OF SILDENAFIL FAST DISSOLVING TABLETS COMBINED WITH SHILAJIT USING CROSCARMELLOSE AND CROSPOVIDONE AS SUPERDISINTEGRANTS

Sidhartha Bora*

Abstract

Sildenafil citrate is the drug of choice for the treatment of erectile dysfunction. Bioavailability of Sildenafil citrate is 41% of orally administered dose. The objective of the present study was to develop fast dissolving tablets of sildenafil citrate combined with Shilajit and to improve its bioavailability, reduce the dosing frequency and thereby maximizing the therapeutic effect of the drug. Sildenafil fast dissolving tablets was prepared by wet granulation method using a combination of superdisintegrants, cfrosspovidone and croscarmellose sodium, shilajit and along with various other excipients in order to confer a therapeutic enhancement on the drug and provide organoleptic characteristics in the final dosage form. Compatibility of the drug and the excipients was investigated by FTIR and DSC studies. Seven formulations (F1- F7) were prepared and subjected to various pre compression and post compression parameters. The results of the formulations were examined after subjecting to variousevaluation parameters. Among all the formulations, batch F7 produced promising results in terms of fast disintegration and dissolution. Hence it was considered as the optimized formulation. Kinetic modeling were carried out on the formulations. Sildenafil citrate fast dissolving tablets were found to be the promising ones,as they increase bioavailability, rapid onset of action, avert the problem of swallowimg and improve the patient compliance.

Keywords: Sildenafil Citrate, Fast Dissolving Tablets, Super Disintegrants, Shilajit


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