Abstract

PHARMACOLOGICAL SCREENING COMBINATION OF PARACETAMOL AND SUCROSE

Sandhya sree.M, B.Rohitreddy, A.Mary Navaneetha, CH. Mounika, A.Rajashekar Reddy, Karthik.M, A Salomy Monica Diyya, J.Gautami

Abstract

Analgesic drugs act in various ways on the peripheral and central nervous systems. Pharmacological screening combination of Paracetamol and sucrose on mice and rats using Tail immersion method, Carrageenan induced rat paw edema method and Antipyretic activity was performed. Test group with paracetmol + sucrose 35% showed maximum analgesic and anti-inflammatory activity with the use of tail immersion and carrageenan method. Prostaglandin analogue like Misoprostol in tail immersion method, the analgesic response was reduced when compared with standard& test groups without prostaglandin analogues. The paracetmol coated with sucrose can be formulated which decreases the rejection of paracetmol for its bitter taste.

Keywords: Analgesic, sweet, prostaglandin.