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Abstract

DESIGN, SYNTHESIS AND EVALUATION OF NOVEL HETEROCYCLES FOR ANTITUBERCULER ACTIVITY

Rahul K. Godge* and Rahul Kunkulol

Abstract

In last few decades, though significant progress has been made in the treatment and control strategies of tubercular infections by introducing new diagnostic and monitoring tools and combination therapy, it still continues to be severe problem. Thus with the aim of developing novel molecule with improved potency for treating Mycobacterium tuberculosis H37Rv strain infections and with decreased probability of developing drug resistance, herein we report the synthesis of coumarin derivatives, starting from salicyaldehyde and ethyl acetoacetate, by convential organic reaction and results of investigations of their antimycobacterial activity. Many compounds have shown promising activity while others were inactive.

Keywords: Coumarin derivative, well diffusion method, elemental analysis.


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