Abstract

SYNERGISTIC ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC AND ANTIOXIDANT EFFECTS OF MOMORDICA CHARANTIA AND METFORMIN IN STREPTOZOTOCIN INDUCED DIABETIC RATS

K. Vijaya, S. Sunitha, P. Abid Husssain Khan, P. Sandhya, D.Sujatha, G. Gopi reddy

Abstract

ABSTRACT Diabetes mellitus (DM) is one of the complex and multifactorial group of disorders characterized by hyperglycemia. In recent years people suffering from diabetes use natural plants along with synthetic drugs in long term treatment of diabetes. Hence the aim of the present study was to evaluate antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanolic fruit extract of Momordica Charantia and standard drug Metformin in combination and alone for treating diabetes. Type I diabetes was induced by streptozotocin (STZ, 65 mg/kg ip single dose) in male albino Wistar rats. The ethanolic fruit extract of Momordica Charantia (500 mg/kg) and standard drug metformin (55mg/kg) was administered orally for 28 days. The blood glucose was estimated upto 28 days. A significant decrease in STZ induced serum glucose (306.38±5.13 mg/dl) was observed with combination (76.16±1.65mg/dl) when compare to drug alone (89.48±3.07mg/dl) and fruit extract alone (82.28±0.714mg/dl). The serum triglycerides levels were also reduced drastically with significant increase in the levels of various antioxidant enzymes when administered in combination as compared to individual dose. Hence it can be concluded that combination of Momordica Charantia and metformin showed beneficial and synergistic effects in the treatment of type I diabetes.

Keywords: Antihyperglycemic, antihyperlipidemic, antioxidant, Momordica Charantia, metformin, streptozotocin.