Abstract

BUCCAL MUCOADHESIVE BASED DRUG DELIVERY DEVICES

*Izhar Ahmed Syed, P. Ravi and John Paul

Abstract

Among the various routes of drug delivery, oral route is the most suitable, convenient and most widely accepted. However, after oral drug administration many drugs are subjected to presystemic clearance in liver, which often leads to a lack of correlation between membrane permeability, absorption and bioavailability. Here the oral cavity is an attractive site for drug delivery due to ease of administration and avoids possible drug degradation in the gastrointestinal tract as well as first pass hepatic metabolism. This is due to direct access of the drug into the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism leading to higher bioavailability. This paper gives a concise review of buccal dosage forms and their formulation accepts in this type of drug delivery technology.

Keywords: Bio-adhesion, Penetration enhancer, Buccal devices, Mucoadhesive polymers.