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Abstract

APPLICATION OF UV SPECTROPHOTOMETERIN METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANIOUS ESTIMATION OF GABAPENTIN AND MECOBALAMINE IN PHARMACEUTICAL DOSAGE FORM

Sonali T. Gade*, Narwate B. M., Swati B. Fulsaundar and Sonawane M.D.

Abstract

Two precise, simple, accurate, reproducible, rapid and economical UVspectrophotometric methods have been developed for simultaneousestimation of gabapentine and mecobalamine in tablet dosage form byusing 0.1N HCL as solvent. Method I is based on formation andsolving of simultaneous equation method, known as vierodt’s method.Gabapentine and mecobalamine show absorbance maxima at 283 nmand 274 nm respectively, so absorbance was measured at the samewavelength for the estimation of gabapentine and mecobalamine intablet combination. Method II is based on principle of Q-analysis,known as absorbance ratio method. Absorbance was measured at 285nm (isobestic point) and 274 nm (λmax of Methylcobalamin.).gabapentine and mecobalamine obeys beer’s law in the concentration range of 5 to 30 μg/ml.Percentage estimation of gabapentine and mecobalamine in tablet dosage form by method Iis 99 and 99.85 and by method II is 99 and 99.89 respectively with standard deviation ≤2.Methods are validated according to ICH guidelines and can be applied for routine analysis ofdrugs in tablet dosage form.

Keywords: Gabapentine and mecobalamine.


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