Abstract

A REVIEW ON THE DETERMINATION OF MIDODRINE HYDROCHLORIDE IN BULK AND MARKETED FORMULATIONS BY USING DIFFERENT ANALYTICAL TECHNIQUES

Ananda Krishna*, M. P. Kavitha and K. Krishnakumar

Abstract

Midodrine Hydrochloride is a Anti hypotensive used for the elevation of supine blood pressure. Midodrine involves the constriction of the blood vessels and increasing the blood pressure. Midodrine hydrochloride is a prodrug which forms an active metabolite Desglymidodrine which activates alpha adrenergic receptors of the arteriolar and venous vasculature thereby increasing the vascular tone and correspondingly blood pressure. Many analytical methods have been reported for the estimation of Midodrine hydrochloride in bulk and marketed formulations. High performance Liquid Chromatography, Ultra Violet Spectrophotometry, High Performance Thin Layer Chromatography etc. have been employed in the analysis. High Performance Liquid Chromatography and Ultra Violet Spectroscopy is been used most widely.

Keywords: Midodrine Hydrochloride, High Performance Liquid Chromatography, Stability Indicating Analytical Methods.