Abstract

A PILOT STUDY ON EFFECT OF METFORMIN IN POLYCYSTIC OVARY SYNDROME

Lakshmi KS*, Jayasutha J, Anjalakshi Chandrasekar3, Muthulakshmi M

Abstract

The objective of the study was to evaluate the efficacy of Metformin in women with polycystic ovary syndrome. A Prospective study was performed in Infertility and Gynaecology Clinic. A total of 50 patients were recruited for the study, of which 8 patients were excluded due to insufficient data and 42 overweight patients with polycystic ovary syndrome was included for the study based on inclusion and exclusion criteria. Metformin 500 mg trice daily was given to each patient. The result of the study shows that 24 patient had oligomenorrhea, of which 18 patients had regular menstrual cycle after treatment with Metformin. 8 patient had amenorrhea, of which 4 patient got regular menstrual cycle after treatment. The Mean±SD of fasting glucose, fating insulin and glucose/insulin ratio were 96.6±14.2, 22.1±5 and 4.3±0.6. After treatment, it was found to be reduced to 93.6±10.2, 18.7±4 and 5.5±1.2. Significantly decreased concentration in hormonal parameters like LH, FSH, LH:FSH and testosterone were also observed. It was concluded that Metformin was found to be effective treatment for polycystic ovary syndrome.

Keywords: Polycystic ovary syndrome, Metfromin, Fasting glucose.