Abstract

ENHANCED DISSOLUTION RATE OF CANDESARTAN CILEXETIL BY LIQUISOLID TECHNIQUE

*Jyothsna Bhimireddy and P. Srinivasa Babu

Abstract

Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation. Therapeutic effectiveness of a drug depends upon bioavailability, ultimately upon the solubility of drug molecules. Candesartan cilexetil is a BCS class II drug which has low solubility and high permeability. By increasing the solubility of the drug, the dose is reduced and bioavailability is increased. This is the main reason to increase solubility of Candesartan by liquisolid technique in which hydrophilicity is imparted to Candesartan by tween. Starch and hydroxy propyl methyl cellulose (HPMC) are used as carrier materials and Aerosil is used as coating material. The solubility is enhanced by 26% using liquisolid technique when compared to pure drug in the dissolution medium.

Keywords: Carrier material, coating material, solubility, bioavailability.