ENHANCED DISSOLUTION RATE OF CANDESARTAN CILEXETIL BY LIQUISOLID TECHNIQUE
*Jyothsna Bhimireddy and P. Srinivasa Babu
Abstract
Solubility is one of the important parameter to achieve desired
concentration of drug in systemic circulation. Therapeutic
effectiveness of a drug depends upon bioavailability, ultimately upon
the solubility of drug molecules. Candesartan cilexetil is a BCS class II
drug which has low solubility and high permeability. By increasing the
solubility of the drug, the dose is reduced and bioavailability is
increased. This is the main reason to increase solubility of Candesartan
by liquisolid technique in which hydrophilicity is imparted to
Candesartan by tween. Starch and hydroxy propyl methyl cellulose
(HPMC) are used as carrier materials and Aerosil is used as coating
material. The solubility is enhanced by 26% using liquisolid technique when compared to
pure drug in the dissolution medium.
Keywords: Carrier material, coating material, solubility, bioavailability.
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