Abstract

GREEN SYNTHESIS AND CHARACTERIZATION OF THORIUM NANOPARTICLES USING ONION (ALLIUM CEPA) EXTRACT AND THEIR ANTICANCER ACTIVITY

Mallikarjun S. Yadawe*, Savita Akale, Malati Chanagond and Vanita Dyavannavar

Abstract

The wide application of nanoparticles stimulates the need for synthesizing them, but the conventional methods are usually hazardous and energy consuming. This leads to focus on “Green synthesis” of nanoparticles which seems to be easy efficient and ecofriendly approach. The thorium nanoparticles were characterized by FTIR, UV spectroscopy, Scanning electron microscopy and transmission electron microscopy. Further, the synthesized thorium nanoparticles were tested for antimicrobial and anticancer activity. From the experiment it was found that the thorium nanoparticles synthesized by using onion have a significant anticancer activity. The in vitro results showed that onion coated thorium nanoparticles presented a dose dependant effect on human melanoma A 375 cell lines.

Keywords: Allium Cepa, Nanoparticles,cell line, Anticancer activity.