ASSESSMENT OF OCIMUM SANCTUM TO NORMALIZE THE ESTROUS CYCLE IN LETRAZOLE INDUCED POLYCYSTIC OVARY SYNDROME IN FEMALE WISTAR RATS
Azmath Farhana*, T Anusha Reddy, Kole Bhavana, Sumith Mutha and Vasudha Bakshi
Abstract
Objective: To assess beneficial effect of ethanol leaf extract of
Oscimum Sanctum in Letrozole induced Poly cystic ovary syndrome in
female Wistar rats. Methods: Letrozole (1 mg/kg) was administered
per orally (p.o) for a period of 21 days for the induction of PCOS,
followed by doses of extract (100 mg/kg and 200 mg/kg, p.o) for 15
days using carboxy methyl cellulose(CMC) as vehicle. Results: The
administration of Letrozole led to abnormalcy in serum sex steroid
profile, glucose and depletion in antioxidant activity. Leaf Extract of
Oscimum sanctum was able to successfully exert its protective effect
by restoring all the parameters to normal and disappearance of cysts in
ovaries. Conclusion: Leaf Extract of Oscimum sanctum showed
beneficial effects in Letrozole induced PCOS in female Wistar rats. Its effect was comparable
to that of Clomiphene citrate, most widely used treatment for ovulation induction in PCOS
condition.
Keywords: PCOS, Letrazole, Oscimum sanctum, Clomiphene citrate.
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