Abstract

ASSESSMENT OF OCIMUM SANCTUM TO NORMALIZE THE ESTROUS CYCLE IN LETRAZOLE INDUCED POLYCYSTIC OVARY SYNDROME IN FEMALE WISTAR RATS

Azmath Farhana*, T Anusha Reddy, Kole Bhavana, Sumith Mutha and Vasudha Bakshi

Abstract

Objective: To assess beneficial effect of ethanol leaf extract of Oscimum Sanctum in Letrozole induced Poly cystic ovary syndrome in female Wistar rats. Methods: Letrozole (1 mg/kg) was administered per orally (p.o) for a period of 21 days for the induction of PCOS, followed by doses of extract (100 mg/kg and 200 mg/kg, p.o) for 15 days using carboxy methyl cellulose(CMC) as vehicle. Results: The administration of Letrozole led to abnormalcy in serum sex steroid profile, glucose and depletion in antioxidant activity. Leaf Extract of Oscimum sanctum was able to successfully exert its protective effect by restoring all the parameters to normal and disappearance of cysts in ovaries. Conclusion: Leaf Extract of Oscimum sanctum showed beneficial effects in Letrozole induced PCOS in female Wistar rats. Its effect was comparable to that of Clomiphene citrate, most widely used treatment for ovulation induction in PCOS condition.

Keywords: PCOS, Letrazole, Oscimum sanctum, Clomiphene citrate.