Abstract

STUDY DIURETIC ACTION OF LEAVES OF MANGIFERA INDICA

Abhishek R. Bura*, Rushikesh S. Wandhekar and Omkar S. Zarekar

Abstract

A dried powder of Mangifera Indica is substituted for extraction using ethyl acetate,60 % ethanol, and water in upper order to polarity prepared. Mangifera Indica L. indicates the presence of alkaloids, tannins, saponins, steroids, flavonoids, terpenes by phytochemical analysis of ethanolic extract. Then diuretic activity tested by Aqueous and 60 % ethanolic extract of Mangifera Indica. Diuretic activity tested by Lipchitz method. In toxicity studies 200mg/kg & 400 mg/ kg dose was selected for given activity. After 24 hours urine output was calculated. In the given study Furosemide (20mg/kg) served as a positive control by giving IP route and by giving IV route and by oral route extracts were given. Na+, K+, Cl concentration in urine was determined by flame photometer instrument.60% ethanoic extract and aqueous extract of Mangifera Indica L. leaves at 400 mg/kg have increased the urine output significantly. These extracts of 60 % EEMI & AEMI at 400 mg/kg b.w. has shown better diuretic activity, whereas moderate diuretic activity was shown at 200 mg/kg dose. From current study, it is concluded that aqueous extract and 60% ethanolic extract of Mangifera Indica L. has diuretic and natriuretic activity.

Keywords: Mangifera Indica L., Na+/ K+ ratio, Extract Activity, Extract, Photochemical.