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Abstract

FABRICATION, APPRAISAL AND PHARMACODYNAMICS OF CURCUMIN LOADED POLYMETHYL METHACRYLATE NANOPARTICLES

Malay K Das and L. Boro

Abstract

ABSTRACT The objective of present study was to develop nanocurcumin for potential application in inflammatory diseases. The particles were prepared by nanoprecipitation with high speed homogenization and ultrasonication. Two polymers namely Eudragit RS 100 and RL 100 were used in combination, with varying ratios. The nanodispersion was further converted to nanocomposite film by solvent casting technique, to make feasible for topical application on skin. The formulations were evaluated in terms of particle size, entrapment efficiency, content uniformity, stability and drug excipient interaction. The permeation properties of nanocomposite films were investigated across pig epidermis in Keshary-Chien glass diffusion cell. The pharmacodynamics properties of the films were evaluated in carrageenan induced rat paw edema model. The SEM and TEM data confirmed the deposition of spherical nanocurcumin in the size range of 55-89 nm. The FTIR and DSC data exhibited no distinct physical or chemical interactions between the drug and polymers. The XRD data indicated the amorphous nature of nanocurcumin in the film. The skin permeability of nanocurcumin was found to be more when compared to plain curcumin. The pharmacodynamics studies in rat model showed that nanocurcumin reduced inflammation more effectively than the oral formulation of same dose.

Keywords: Nanocurcumin, Nancomposite film, Pharmacodynamics.


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