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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING FILM OF VARDENAFIL HCL

Prashant Nadavadekar and Mrs Sheeja Koliyote

Abstract

The present study aimed at preparing fast dissolving oral films of Vardenafil HCL which is used to treat erectile dysfunction. Fast dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties. In present research work films were prepared by solvent casting technique using polymers such as Kollicoat IR and PVA. The prepared films were evaluated for film thickness, folding endurance, tensile strength, % elongation, disintegration time, drug content uniformity and drug release. The FTIR studies revealed that there is no physical interaction between drug and polymer. The optimized formulation F5 (B) prepared using Kollicoat IR shows better results for weight (37mg), thickness (0.10mm), tensile strength ( 3 gm /cm2), % elongation (5.5%), folding endurance (32), surface PH (6.84), drug content uniformity (101.09). The formulations were subjected to disintegration (14 seconds); in vitro drug release (101.94%) and stability study (it revealed that optimized formulation was stable). FDF of Vardenafil HCL can be considered suitable in treatment of erectile dysfunction.

Keywords: Erectile dysfunction, Fast dissolving dosage form, Kollicoat IR, Vardenafil HCL.


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