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Abstract

STUDY ON SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF POORLY WATER SOLUBLE DRUG ROSUVASTATIN CALCIUM

Chetan Amrutkar, Kishor Salunkhe, Sanjay Chaudhari

Abstract

The aim of the present study is to improve solubility and hence bioavailability of Rosuvastatin calcium using self nanoemulsifying drug delivery system (SNEDDS). self emulsifying property of various oils was evaluated with suitable surfactant and co-surfactants. Ternary phase diagram was constructed based on Rosuvastatin calcium solubility analysis for optimizing the systems. The prepared formulation were evaluated for self emulsification time, dispersibility study, average globule size, Polydispersibility index (PDI). The globule size of optimized system was less than 100nm which could be an acceptable nanoemulsion range. The average globule size of the selected F2 SNEDDS formulation (Capmul MCM [20%], Tween 20 [40%] and PEG 200 [40%]) was 88.01nm. In vitro drug release studies showed remarkable increase in dissolution of F2 SNEDDS compared to marketed formulation.

Keywords: Self nanoemulsifying drug delivery system; SNEDDS; Rosuvastatin calcium; solubility study, Ternary Phase Diagram.


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