Abstract

QUANTUM ANALYSIS OF THE CYCLIC ADENOSINE MONOPHOSPHATE (AMPc) AND GUANOSINE MONOPHOSPHATE CYCLIC (GMPc) IN NEUROTRANSMITTERS

Manuel Aparicio-Razo, Javier Flores-Méndez, Bernardino Calixto Sirene, Juan Manuel Jiménez-Rodríguez, Oscar Sánchez-Parada, María del Rosario Leticia Cabrera-Lara, Germán Barrientos-Cabrera and Manuel González-Pérez*

Abstract

Escherichia coli is a gram-negative bacteria in the form of bacilli that is part of the intestinal flora of birds and mammals. This bacterium has several mechanisms to adapt to its environment, among which is the generation of thermolabile enterotoxin that can cause high levels of GMPc y AMPc. Recent studies have found that the presence of this bacterium can be related to various neurological pathologies, since it is known that there is a bidirectional neurohumoral communication system, known as the gut-brain axis. The objective of the study is to determine, by means of the parametric semi-empirical parametric method (SE-PM3 / 1), which neurotransmitters have a greater affinity with the GMPc y AMPc, in order to understand the neuronal oxidative effect. The Hyperchem Professional software performed the Molecular Modeling and Analysis of the molecules of GMPc/AMPc and 9 of the main neurotransmitters. (Hyperchem, Hypercube, Multi On for Windows, Series 12-800-1501800080. Multi On, South 1236-301 Tlacoquemecatl Insurgentes Col. Del Valle, Benito Juarez, Mexico, CP 03200). The result of the simulations of quantum wells reveals that these nucleotides have the ability to oxidize Adrenaline, which suggests that it may be linked to the neurological disorders of various diseases.

Keywords: Neurotransmisores, Neurodegeneración, Escherichia-coli, AMPc, GMPc, Quantum Method, Hyperchem, SE-PM3.