Abstract

IN VITRO STUDY OF THE EFFECT OF CORN SILK ON GLUCOSE UPTAKE BY ISOLATED RAT HEMI-DIAPHRAGM

Ghada. M , Eltohami M.S,Adurahman H. N, Mahmoud M. E. Mudawi

Abstract

the present study the methanolic extract of corn silk was evaluatedfor antidiabetic activity. The antidiabetic activity was studied using theglucose uptake by isolated rat hemi-diaphragm using in-vitro model.Corn silk increased the uptake of glucose by isolated rat hemidiaphragmsignificantly (P<0.001) and was found to be more effectivethan insulin. It appears that corn silk has direct peripheral action onglucose uptake. The value of glucose uptake by rat hemi-diaphragmafter addition of corn silk extract was 109±1 as compared to control(12± 1) and Insulin (49 ± 8)mg/g/30min .These results strongly suggestthat Corn silk will be alternative choice for the treatment of diabetesmellitus.

Keywords: Anti-diabetic, Rat hemi-diaphragm, corn silk, Glucose uptake.