Abstract

ACUTE AND REPEATED ORAL TOXICITY OF SIDDHA METALLOMINERAL FORMULATION SEENA RASA CHENDURAM (SRC)

S. Sudha* and R. Madhavan

Abstract

Seena rasa chenduram (SRC) a Siddha drug which is prepared from Mercury, Sulphur and Alum is indicated for hemorrhoids and venereal diseases in the text Anuboga vaidhiya navaneetham. In siddha system of medicine metals and minerals are widely used to cure the diseases for many years. There is a need today to evaluate the safety profile of siddha mineral preparations. Acute and 28days repeated oral toxicity studies were performed according to OECD guidelines in Wistar Albino rats. In acute toxicity study the dose level of 5, 50,300, 2000mg/kg body weight was administered stepwise. 28 days repeated oral toxicity study was carried out at different dose levels X(9.36),5X(46.8),10X(93.6) and the control group of animals were administered vehicle only. Acute toxicity study concludes that LD50 of SRC is 1000mg and it comes under CAT- V (GHC) as per the OECD-423 classification. At the end of 28 days repeated oral toxicity study there were no abnormal signs were found during the study period. Acute and repeated oral toxicity studies of SRC revealed that SRC is safe for human consumption.

Keywords: Seena rasa chenduram, Hemorrhoids, Toxicity study, Siddha drug, Mercury.