Abstract

EVALUATION OF THE EFFICACY AND SAFETY OF COMPLEX THERAPY OF ACUTE RESPIRATORY DISEASES OF ADENOVIRAL ETIOLOGY IN YOUNG PEOPLE

Malyshev Nikolay Alexandrovich*, Lvov Nikolai Ivanovich and Maltsev Oleg Veniaminovich 

Abstract

An important current epidemiological phenomenon is the simultaneouscirculation of different types and strains of viruses, including influenzaviruses, as well as the presence of mixed infections - influenza andother acute respiratory viral infections in one patient. Adenovirusinfections occupy a leading position in the general structure of acuterespiratory viral infections, especially in periods when influenza rarelyoccurs. Bearing in mind the particular clinical course of adenovirusinfection, the principal challenge of antiviral therapy, in addition torelieving the manifestations at the height of the disease, is to suppressadenovirus persistence and reduce the frequency of development oflate pneumonias and a protracted and recurrent clinical course. Aretrospective analysis of case histories where interferon inducers andinterferons were used to treat adenoviral diseases in young peopleestablished that Kagocel, an inducer of the "late" interferons, significantly decreased theincidence of pneumonia and a protracted and recurrent course compared with the baseline(pathogenetic) therapy.

Keywords: Adenoviral disease, antiviral therapy, interferon, tilorone, meglumine acrid?nacetate, Kagocel.