Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF RIZATRIPTAN BENZOATE ORAL DISINTEGRATING TABLETS

Sujatha Banavath*, Ragya Eslavath, Ch. Yella Reddy, R. Suthakaran, J. Shiva, U. Ramakrishna and Goli. Venkateshwarlu

Abstract

To formulate and evaluate Rizatriptan benzoate oral disintegrating tablets to prepared the various formulations and perform the precompression parameter and post compression parameters. Direct compression method was used for the preparation of oral disintegrating tablets of Rizatriptan. prepared drug parameters compared with standard drug MAXALT MLT parameters. based on the preliminary studies various formulation trials (f1-f11) were carried out with different concentrations of superdisintegrants and diluents. from the various formulations it was concluded that the formulation f11, the reproducibility batch of f5 was finalized as the optimized formula. formulation f11 showed satisfactory results with various physicochemical evaluation parameters like hardness, percentage weight loss, disintegration time, dissolution profile when compared with the marketed product.

Keywords: Direct compressiom method, cross povidone polyme, Rizatriptan Benzoate, Phosphate buffers.