Abstract

DIABETES: QUANTUM ANALYSIS OF THE INTERACTIONS OF CARNOSINE AND OTHER DIPEPTIDES VS. GLUCOSE

Dr. Manuel Gonzalez-Perez*

Abstract

The treatments with carnosine and other peptides have revolutionizedscience in recent years. Researchers show that treatment with carnosineimproves glucose (GLU) metabolism, albuminuria, and pathology. Theobjective of this research was to analyze the chemical-quantuminteractions of GLU with pure amino acids (AAs) and dipeptides. Thehyperchem simulator was used to perform quantum calculations. Thesecalculations are based on the Electron Transfer Coefficient (ETC). Thefollowing discoveries were made: the GLU is very aggressive and canattack any AA in its pure state. GLU also attacks dipeptides,polypeptides, and biological tissue. Carnosine has an ETC = 33.824,and there are other dipeptides with lower ETC. All dipeptides ofHistidine (His) keep their ETC value = 33.824 constant, which is theETC value of carnosine. It concluded that all dipeptides of His musthave similar behavior to carnosine. Laboratory studies of these Hisdipeptides are suggested in order to control blood GLU and nephropathies for diabeticpatients.

Keywords: Diabetes, Quantum chemistry, Carnosine, Dipeptides, Glucose.