Abstract

SYNERGISTIC EFFECT OF SOLID DISPERSION AND INCLUSION COMPLEX IN ENHANCING THE SOLUBILITY AND STABILITY OF POORLY SOLUBLE DRUGS

Kofi Oti Boakye-Yiadom, Samuel Kesse, Mensura Sied Filli, Md. Aquib, Faisal Raza, Reyaj Mikrani and Wang Bo*

Abstract

Majority of medications produced are known to be either weakly acidic or weakly basic with poor aqueous solubility properties. As a result, a variety of techniques utilized for the improvement of the solubility properties of poorly water-soluble medications which include micronization, pH adjustment, co-solvency, complexation, cocrystallization, hydrotrophy, etc. Poor bioavailability of drugs is a stumbling block in drug formulation in that active drug moiety does not get to the target site for pharmacological response to be elicited. Inclusion complexation and solid dispersion are among some techniques that can be used to curtail this problem. Before a particular solubility technique is chosen a few issues come to play; drug property, site of absorption, and required dosage form characteristics. By and large, both techniques thus solid dispersion and inclusion complex when used alone or in combination one way or the other enhances the solubility, dissolution rate and bioavailability of drugs. And this eventually improves wettability and results in decreased particle size, amorphous-structured particles, and higher porosity degree. This review highlights the need for this combination to enhance the solubility of poorly soluble drugs.

Keywords: Solubility, Bioavailability, Stability, Dissolution, Solid dispersion, cyclodextrin.