Abstract

MICROSPONGE DRUG DELIVERY FOR PERIODONTITIS: A REVIEW

Mayura Chavan*, Sarika Nikam and Abhijit Khanore

Abstract

Periodontal disease is a chronic inflammatory disease of gum tissue of teeth, If not treated may cause mobility & loss of tooth. The current practice in treatment of periodontitis involves scaling and root planning followed by administration of systemic antibiotics or application of local antibiotics directly on gums several times as adjuncts to conventional mechanical therapy. Systemic administration of antibiotics has disadvantages like inability of drug to attain satisfactory concentration at the site of action, nausea, fever, abdominal pain, unnecessary exposure of body to high dose of drug etc. These disadvantages have led to the development of local application of antibiotics which are intended to exclusively affect bacteria within the periodontal pocket. Dosage forms like mouth washes, lotions, gel, film, strip or pastes suffer common disadvantages such as low contact time; drug is lost in the saliva, has low patient compliance, need of frequent drug application and may have ability to develop resistance to the drug. The sustain release formulation release antibacterial drug at the site of infection (periodontal pocket) and also include ease of drug delivery at site of infection, sustain release of drug into GCF (Gingival Crevicular Fluid) for desired period of time. Microsponges fulfill all these need using insoluble or slightly soluble drugs. Microsponge reduce the dose of drug and avoid unnecessary exposure to whole body by providing the sustain delivery of oral medication. The goal of this review is microsponge drug delivery is very advance and useful to deliver the drug in periodontal pocket and its therapy.

Keywords: Periodontal disease Periodontal Pocket, Gingival Crevicular Fluid, Microsponge.