Abstract

IN VITRO DESIGNING OF LORATIDINE-GELUCIRE SOLID DISPERSIONS

M. Swetha*, Bhanusri B., Ch. Dhanalakshmi, G. Natesh and R. Sagar

Abstract

The aim of present work to improve solubility and bioavailability of Loratidine by preparing solid dispersion with the combination of gelucire 44/14 and 50/13 as a hydrophilic carrier by using solvent evaporation method. In present work 9 formulations of Loratidine solid dispersion were prepared by solvent evaporation method by using different ratios of carriers. All the formulations were subjected to solubility studies, powder characteristics and drug release studies out of 9 formulations F3 and F6 containing Gelucire 44/14(1:3) and Gelucire 50/13 (1:1) showed complete drug release with in 15 minutes. The optimized solid dispersions were punched to fast dissolving tablets and evaluated for various physico chemical properties. The percentage drug release in 15min(Q15) and initial dissolution rate (IDR) for optimized formulation was 94.22 ±1.08%,copared to pure drug (23.87±1.13%) solubility is improved. The improvement in the dissolution characteristics of drug described in terms of dissolution efficiency (DE) and relative dissolution rate (RDR). The RDR was found to be 2.14 and DE 67.52 and it is increased by 4 folds with optimized formulation compared to conventional tablets.

Keywords: Solid dispersion, solubility studies, powder characteristics, drug release studies, IDR, DE, RDR.